After conquering the Boneyard stage in Mewgenics, the atmosphere of your digital cattery shifts. You’ll receive a chilling warning about the impending arrival of Guillotina, one of the game’s most notorious raid bosses. Unlike standard encounters that happen during a run, Guillotina is a unique threat because she invades your home base.
As we explore in this guide, defending your feline family requires a shift in strategy. When Guillotina arrives, you must rely on your retired cats to protect the household. Failure isn’t just a loss of progress; she will literally bite your cats’ heads off. Here is how to prepare your roster and secure victory against this home-invading menace.
Strategic Preparation: The Seven-Day Countdown
Once the warning triggers, you are granted seven in-game days to prepare. You can track this countdown in the top-left corner of your screen while at home. While the temptation to skip ahead exists, a “measure twice, cut once” approach—familiar to any software engineer or strategist—is vital here. Guillotina is a massive difficulty spike that rewards thorough preparation.
The core constraint is that you can only use four retired cats for this fight. This makes your long-term breeding program essential. To build an elite defense force, focus on:
- High-Quality Breeding: Mate your strongest retired cats to pass down elite stats and specialized skills.
- Home Management: Use high-quality furniture to boost your Comfort stat. This prevents your prime defenders from killing each other in nightly scraps or focus-draining domestic disputes.
- Gear Acquisition: Use your remaining runs before the boss arrives to scavenge for high-tier armor and weapons. Guillotina’s health pool is massive, and you’ll need every stat point available.
Recommended Class Composition
To ensure your home remains safe, TechTalesLeo recommends a balanced party that covers range, sustain, and raw power:
- Hunter: Your primary ranged engine. Utilize Marked and Arrow Flurry to chip away at Guillotina from a distance.
- Fighter: The frontline anchor. High Strength is a must, but Intelligence and Constitution are equally important to keep the pressure on up close.
- Cleric: Essential for sustain. Without a Cleric, a prolonged fight with Guillotina almost always ends in a decapitation.
- Necromancer: Excellent for consistent damage and self-healing. Avoid reanimation skills, as there are no “mobs” to resurrect; focus on leeches and direct pressure.
- Thief: The “glass cannon” option. If you can manage their positioning, their backstab damage can significantly shorten the encounter.
How to Beat Guillotina: Combat Tactics
Guillotina arrives with a staggering 500 Health and a penchant for Area of Effect (AoE) attacks. The golden rule for this encounter is spatial awareness. Spreading your cats out is the best way to mitigate her damage-over-time effects and knockback mechanics.
| Attack Name | Description & Effect | Best Counter-Strategy |
|---|---|---|
| Slice | A two-tile basic attack with knockback. | Keep cats separated so she cannot hit two at once. |
| Groundpound | A short leap causing damage in a 4×4 grid. | Stay away from the arena edges to avoid being knocked out of bounds. |
| Toss | Grabs and throws a cat across the arena. | Use high-speed skills like Alpha to get melee cats back into position quickly. |
| Inhale | Temporarily removes a cat from the battle. | Use Flail (25% escape chance) or deal burst damage with remaining cats to force a release. |
| Movement | Passive damage and knockback just by walking. | Maintain distance; she occupies four tiles and deals damage simply by repositioning. |
In addition to positioning, focus on status effects. Bleed, fire, and leeches are incredibly effective at whittling down her health while your Hunter and Fighter fish for critical hits. A well-timed crit from a high-Luck Hunter can deal 50+ damage, swinging the momentum in your favor.
The Spoils of Victory: Ultra Retirement
Defeating Guillotina grants you the Throbbing Gristle quest item. This is a high-stakes item—take it to the Wall of Flesh at the end of the Caves immediately, but be careful not to lose it in a subsequent run.
After the fight, speak to Butch. Your four brave defenders will be elevated to “Ultra” retired status, marked by a glowing crown. While they can no longer participate in home defense (they’ve earned their peace!), they remain in your cattery and can still be used for breeding. This ensures their elite genes continue to power your future generations in the strange, wonderful world of AI-driven feline evolution.
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