Cracking safe codes in Resident Evil Requiem is more than just a survival tactic; it’s a vital strategy for any player looking to maximize their efficiency. At Digital Tech Explorer, we’ve put these puzzles to the test to ensure you can secure those elusive Antique Coins and essential early-game upgrades. Whether you are aiming for a Hip Pouch to expand your inventory or a Stabilizer damage upgrade for Grace, these safes hold the keys to your survival.
After thorough testing by our team, I can confirm that these safe codes remain consistent across all playthroughs. Below is your comprehensive guide to finding every safe in the Care Center, the specific combinations needed to open them, and a breakdown of the loot inside. When entering these codes, remember to turn the dial in the specified direction and only attempt to open the safe once all three numbers have been entered.
Safe Codes Quick Reference Table
| Safe Location | Combination | Key Rewards |
|---|---|---|
| Bar and Lounge (1F West Wing) | 10 (Left), 80 (Right), 30 (Left) | 3x Antique Coins |
| Examination Room (East Wing) | 30 (Right), 10 (Left), 50 (Right) | 3x Antique Coins |
| Basement (Near Inspection) | 60 (Right), 40 (Left), 80 (Right) | Handgun Ammo, Raccoon Roundup Map |
| Sterilization Chamber | 10 (Right), 90 (Left), 20 (Right) | Ammo, Med Injector, Molotov |
| Monitor Control Room | 50 (Left), 60 (Right), 80 (Left) | Acid Bottle, Med Injector, Empty Bottle |
Bar and Lounge Safe
Located on the first floor of the West Wing, you will find this safe tucked behind the bar. Use the following sequence: 10 (left), 80 (right), 30 (left). Opening this safe rewards you with three Antique Coins.
Pro Tip: While you are in this area, don’t miss Grace’s S&S M232 pistol located behind the bar. You can also find an additional Antique Coin on the piano stool. Be wary of the singing zombie nearby; her scream can disrupt your aim and leave you vulnerable to other threats in the room.
Examination Room Safe
You can access the Examination Room in the East Wing after unlocking the unicorn door into the Parlor and securing the keycard. The safe is housed inside a cabinet near the organless corpse. The combination is 30 (right), 10 (left), 50 (right).
Inside, you will find another three Antique Coins. For context, the combination is found on a document located behind the area where the Chunk manifests near the Lead Researcher’s Office. Additionally, check the Waiting Room behind the counter for an already open safe containing more coins.
Basement Safe
This safe becomes accessible after switching between Leon and Grace. It is situated near the forklift-blocked Inspection area. You will need to use a joint plug to power the door near the Furnace room to reach it. The code is 60 (right), 40 (left), 80 (right).
Beyond handgun ammo, this safe provides the Raccoon Roundup map, which is essential for tracking down Mr. Raccoon Memoriam statues. Leon discovers the clue for this code earlier in the game while exploring the attic.
Sterilization Chamber Safe
Encountered in the later stages of Resident Evil Requiem, this safe is on the north side of the Sterilization Chamber. This occurs during the sequence where Grace is working to bypass the central refining system. The combination is 10 (right), 90 (left), 20 (right).
Opening this safe provides high-value survival items: handgun ammo, a med injector, and a molotov cocktail for crowd control.
Monitor Control Room Safe
The final safe in this section is located in the Monitor Control Room, just off the Lobby. Use the combination 50 (left), 60 (right), 80 (left).
This safe is particularly useful for crafting and health, containing an empty bottle, a bottle of acid, and another med injector.
Explore More Resident Evil Requiem Guides:
• Antique Coin Locations: Maximize your parlor upgrades.
• Inventory Management: How to find every Hip Pouch.
• Puzzle Solutions: Step-by-step guides for the Trick Boxes.
• Charm Locations: Enhance your abilities with hidden collectibles.
• Lockpicking Guide: How to open simple locks throughout the facility.
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